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When should you take amantadine? For treatment of Parkinson's disease or movement problems (including dyskinesia): For oral dosage forms (extended-release capsules): Adults—137 milligrams (mg) once a day at bedtime. Your doctor may increase your dose to 274 mg (two 137 mg capsules) once a day at bedtime after one week. Does Parkinson's have flare ups? Another common assumption is that PD can " flare up " unexpectedly. Although symptoms may fluctuate throughout the day, the progression of PD is very slow. Reality. If PD symptoms worsen over days or weeks, then it is critical to search for an underlying cause. Does Sinemet cause tiredness? Fatigue due to Medications - Dopamine agonists, such as Mirapex and Requip, can cause fatigue and daytime sleepiness. o Reducing the medication may help; however, it can come at the cost of increased PD motor symptoms.
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