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five goals therapy malaria How long does quinine take to work? You may need to take quinine for about four weeks before you feel the full benefit. Does Quinine interact with medications? Quinine has no known severe interactions with other drugs. Serious interactions of quinine include: cisapride. dronedarone. Does tonic water relieve leg cramps? Q. It's been suggested that drinking 2 to 3 ounces of tonic water before bedtime can prevent leg cramps at night. A. Tonic water —and the quinine it contains—have been promoted for preventing leg cramps for decades despite the lack of evidence that they are effective. 6c269p1c