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What antidepressant is similar to Pristiq? Trintellix (vortioxetine) and Pristiq (desvenlafaxine) are antidepressants used to treat major depressive disorder (MDD). Trintellix is a selective serotonin reuptake inhibitor (SSRI) and Pristiq is a selective serotonin and norepinephrine reuptake inhibitor (SNRI).
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