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Is Methotrexate used to treat cancer? Uses. Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system. What should you avoid while taking methotrexate? Avoid unnecessary or prolonged exposure to sunlight and wear protective clothing, sunglasses and sunscreen. Do not use sunlamps during your treatment with methotrexate. If you have psoriasis, your sores may get worse if you expose them to sunlight while taking methotrexate.
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