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What happens if you take too much methotrexate? Adverse and toxic effects of methotrexate Adverse effects of methotrexate can occur at therapeutic levels and include headache, malaise, mouth ulcers and hairfall. In overdose, vomiting, diarrhoea and gastrointestinal bleeding may occur, as well as severe bone marrow suppression and disturbance of liver function.
What kind of medicine is methotrexate? Methotrexate belongs to a class of drugs known as antimetabolites. It works by slowing or stopping the growth of cancer cells and suppressing the immune system.
Why is my Methotrexate not working? Treatment with methotrexate alone isn't working well enough. This is the most common reason for taking biologics. Your doctor will regularly examine your joints and test your blood for signs of RA. If methotrexate isn't helping enough, he or she might add a biologic.
Do you take chemo pills everyday? You may take oral chemo daily, weekly, or once or twice a month. Chemo is often given in cycles over a period of several months or more. This means that you will get the medicine for a period of time, and then you will have a break from it. This allows your body to grow new, healthy cells.
How is methotrexate eliminated from the body? Excretion. Renal excretion is the primary route of elimination and is dependent upon dosage and route of administration. With IV administration, 80% to 90% of the administered dose is excreted unchanged in the urine within 24 hours. Methotrexate clearance rates vary widely and are generally decreased at higher doses.
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